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GC-MS and HPLC-MS analysis

GC-MS and HPLC-MS analysis

Additional Information for GC -MS and HPLC -MS analysis

Gas chromatography (GC):

GC analysis is a method for separating mixtures into their individual chemical compounds. The GC is only applicable for components that are gaseous or vaporized without decomposition (boiling range up to 400 C, molecular weight <500u ).

High performance liquid chromatography (HPLC):

The HPLC is a liquid chromatography method with which mixtures can be separated into their individual chemical compounds. In contrast to gas chromatography, which is a very good method for separating vaporizable materials, non-volatile substances can be analyzed by HPLC. Whether this separation method can be used for separating a mixture of substances depends mainly upon whether all of the substances of the mixture can be dissolved in the mobile phase, and if there is a stationary phase having a sufficient selectivity between the substances.

Mass spectrometry (MS):
MS referred to methods, the mass of molecules can be obtained
The MS is an important method of analytical chemistry in the elucidation of the structure of compounds and the composition of mixtures. The qualitative (detection of (un)known substances) and quantitative (how much substance is present) detection of very small amounts of substances is possible.

GC-MS or the HPLC-MS is the coupling of a gas chromatograph (GC) or a liquid chromatograph (HPLC) with a mass spectrometer (MS).
In this case, the GC or HPLC is used for the separation of the substance and the mass spectrometer for the identification and / or quantification of the individual substances.

From the information of relative area percentages of a qualitative analysis, no conclusion can be drawn on the exact composition of the sample or the content of a particular substance. The specification indicates only an approximate composition of the mixture. The actual composition can vary greatly due to serious different response factors.

Please contact us if you have further questions to the listed analytical procedures.