New high-resolution tandem mass spectrometer (Q-ToF)

After 2 years of planning, we are pleased to break new ground in the field of analytics and to expand our analysis portfolio for you. Since March 2020, the installation of the new analytical instrument (LC-MS) has been successfully completed.

The system consists of the ACQUITY UPLC I-Class Plus, the ACQUITY UPLC Photodiode Array Detector (PDA) and the high-resolution mass spectrometer Xevo G2-XS QToF from Waters.

The new instrument enables us not only to identify and quantify known substances, but now also gives us the possibility to identify yet unknown compounds such as NIAS. We have various tools at our disposal for this: Building substance libraries, linking to online databases, Mass Fragmentation Tool, etc.

We are also able to create customised substance libraries for your project in order to check for their presence in your samples.

High resolution mass spectrometry (HRMS) allows us to measure the mass of molecules to 4 decimal places, with an accuracy of 2 mDa. This allows us to generate molecular formula suggestions for unknown compounds. The MSE technology also simultaneously records high-energy spectra (fragmentation spectra), which provide us with additional information for the identification of the detected substances. It is important for the simultaneous measurement that coelution of substances is avoided. By coupling with UPLC and using sub 2 µm columns, a very good separation performance is achieved.

In addition to this screening approach, classical MSMS experiments can also be carried out on complex samples.

In cooperation with Waters, an application note entitled "Strategies for Targeted and Untargeted Screening of Printing Ink Photoinitiators and Acrylates in Migration Studies Using UPLC and Quadrupole Time-of-Flight Mass Spectrometry" was published.

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